MECHANISM OF ACTION (MOA) / PHARMACOKINETICS
BANZEL® (rufinamide) is a triazole derivative structurally unrelated to currently available AEDs1
- Clinical significance has not been established
- The precise mechanism(s) of action of BANZEL is unknown. It is thought to prolong the inactive state of sodium channels1
Pharmacokinetics
- Metabolic route is not cytochrome P450-dependent: metabolized by carboxylesterases1
- Well absorbed orally with a tmax of 4-6 hours1
- However, the rate of absorption is relatively slow and extent of absorption is decreased as dose is increased
- Steady state is reached within 2 days2
- Plasma elimination half-life (t1/2) is approximately 6-10 hours1
- Low protein binding (approximately 34%)1
- The pharmacokinetics of BANZEL in the pediatric population (age 1-17 years) is similar to that in adults1
- References: 1. BANZEL® (rufinamide) prescribing information, Eisai Inc. 2. Perucca et al. Rufinamide: clinical pharmacokinetics and concentration-response relationships in patients with epilepsy. Epilepsia. 2008;49(7):1123-1141.